Biotech Biomaterials in .NET

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FIGURE 4.15 Biomaterials research and development process in relation to the
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Continuum Model milestones (italics).
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R&D Focus Self-Assembling Materials Intelligent Materials Mimetics Nanomaterials
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Markets Consumer, Military, Medical Consumer, Military, Medical General, Military, Medical Medical, Military, Computing General, Military, Medical
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Potential Products Drug delivery vehicles, microsurgical devices Shape memory alloys, arti cial muscles, adaptive clothing Robotics, remote vision, touch, and odor sensors Drug and gene delivery vehicles, imaging agents, and ultradense wiring of electronic chips Self-repairing clothes, mechanical parts, and structural implants
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FIGURE 4.16 High-risk, high impact materials research and development areas.
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Nanomaterials or, more properly, nanostructured biomaterials, con tain molecule-sized structures that enhance the properties of the material. For example, because nanotubes microscopic tubes of graphite can con duct electricity, they can form the basis for the next generation of ultra high density integrated circuits. These molecular electronics may be grown, using self-assembling nanotubes. A related means of providing ultra-highdensity circuit wiring is to use yeast proteins that self-assemble into wires that spontaneously bond with gold contacts. This technology, developed at the Whitehead Institute in Cambridge, Massachusetts in 2003, portends a future of ultracompact computers and supercomputers the size of current desktop computers. Self-healing materials are a form of mimetics in that most conventional nonliving structures are incapable of the self-repair seen in the normal healing of tissue or bone in the body. The applications of self-healing biomaterials range from automatic sealing of biological containment suits in battle to automatic repair of structural implants, such as replacement hips and knees. One reason that many of the developments have immediate or at least short-term applications in the military is because the military lacks many of the traditional market forces that would obviate investment in a highrisk research and development venture. As described in the following sec tion on the military biotech market, the military is the source of funding for a variety of biotech technologies that may have military signi cance.
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The contribution of biotech to the military, while obvious in the era of bio logical warfare, is dif cult to quantify in terms of market activity because of the need of many governments to conceal their activities. Research and development activity in the area of offensive biotech weapons is especially speculative, even though recent discoveries in the areas of pathogen ge nomics, plant genomics, and bioregulation of the immune system have ob vious implications for biowarfare. Although of cial admonition of such developments is absent, the World Health Organization s 2002 report on Genomics and World Health asserts that there is no doubt that many coun tries, including the United States, hold pathogens or potential pathogens in university and government laboratories. Of note is that the misuses of biol ogy for any purpose is prohibited by the 1975 Biological and Toxin Weapons Convention. However, the results of the convention were not rat i ed, in part because the participants could not agree on an effective veri cation procedure. Given these caveats, based on publicly available documents and pro
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Military Biotech
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grams that involve outreach to the industrial community, it is possible at least to approximate the market for military biotech. At the highest level, the proportion of government money earmarked for defense purposes and devoted to research and development provides some indication of the pool of money available for military sponsored research and development in biotech. As illustrated in Figure 4.17, government support for military re search and development, as a percentage of all government research and development for the G-8 countries (United States, Japan, Germany, France, Italy, Great Britain, Canada, and Russia) is greatest in the United States, which devoted approximately 53 percent of its total government funded research and development budget to defense in 1999. Second and third in proportion of military research and development to total research and de velopment expenditure were the United Kingdom and the Russian Federa tion, with about 35 and 30 percent, respectively. France was fourth with about 22 percent. Germany, Canada, Japan, and Italy each contributed sig ni cantly less than 10 percent of their total government-sponsored re search and development to defense.
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