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1,3-Butadiene, 122 2-Butanol, 140 C Cadmium, 41, 46, 51, 52, 275, 318 Calcium homeostasis, 266 Cancer incidence and mortality, 228 231 lung, 318, 321, 322 nasal, 318 process, 225 227 susceptibility, 229 230 Capillary electrophoresis, 454 CAR see Constitutive active receptor Carbamate(s), 20, 60, 221, 408, 471, 477 Carbaryl, 123, 473 Carbasone, 265 Carbofuran, 464 Carbohydrates, metabolic effects, 164 Carbon monoxide, 36 spectrum, 114 Carbon tetrachloride, 4, 123, 153, 156, 173, 189, 265, 269, 274 Carbophenothion sulfoxide, 134 Carboxylesterase, 135 Carcinogen(s), 3, 121, 528 classi cation of human carcinogens, 233 237 direct-acting, 237 epigenetic, 239 240, 528 genotoxic, 237 238, 528 indirect-acting, 237 known human, 233 235 procarcinogen, 150 parent, 240 proximate, 150, 240, 528 ultimate, 150, 240, 528 Carcinogenesis, 6, 225 250, 267, 528 rodent bioassay, 233 234 testing, 371 378 Carson, Rachel, 9 Catechol O-methyltransferase, 142 Cell culture cell lines, 15 induction, in cultured cells, 15 monolayer, 14 suspension, 14 techniques, 13 16 toxicity, in cultured cells, 14 16 Cell membrane, 16, 78 80 Cell transformation test, 392 Cellular methods, in toxicology, 13 22 Cellular respiration, inhibition, 223
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Central nervous system (CNS), 279 280, 379 CERCLA see Comprehensive Environmental Response, Compensation and Liability Act C-Esterase see Esterase Checkpoint, 248 Chelation therapy, 54, 408 Chemical use classes, 7 Chemical exposure classes, 11 Chemical mixtures, 432 Chlordane, 356, 470 Chlordecone, 473 Chlorfenvinphos, 125 Chlorine, 318 p-Chlorobenzaldehyde, 134 1-Chloro-2,4-dinitrobenzene, 144 Chloro uorocarbons, 475 Chloroform, 153, 265, 274, 277, Chloroform metabolites, 153, 277 Chloromethylbenzene, 144 p-Chlorothiophenol, 141 Chlorpromazine, 126, 129, 265 Chlorpyrifos, 59, 122 Chlorthiazide, 265 Cholchicine, 265 Cholestasis, 266 Cholesterol, 119 Cholinesterase, 471 see also Acetylcholinesterase Chromatography, 450 455 column, 452 gas-liquid, 404, 451 high-performance liquid, 404, 454 paper, 450 thin-layer, 403, 450 Chromium, 46, 53, 318 Chromosome aberration tests, 390 Chromosome translocation, 245, 248 Chronic toxicity see Toxicity Chronic value, 473 Cigarette smoke, induction by, 199 Cimetidine, 129 Cirrhosis, 266 Clara cells, 318, 323 Clean Air Act, 412 Clean Water Act, 412 Clearance, 106 Clinical drugs, 4, 7 Clinical toxicology see Toxicology Clo brate, 139, 191 Cloning, molecular, 17 CNS see Central nervous system
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INDEX
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CoA see Coenzyme A Coal dust, 318 Cobalt, 4 Cocaine, 205 Cocarcinogenesis, 528 Coenzyme A (CoA), 146 Columns, 450, 451 Combustion products, 7 Compartment, 106, 528 Compartmentalization, 204 Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), 413 Conjugation reactions see Phase II reactions Constitutive active receptor (CAR), 195 Consumer Products Safety Act, 354, 413 Consumer Products Safety Commission Improvements Act, 413 Contact hypersensitivity, 337 338 Controlled Substances Act, 413 Cooxidation, 132 Copper, 4, 165, 166, 492, Cortisol, 300 Cosmetics, 71 Coumaphos, 126 Coumarin, 122, 138 Courtroom testimony, 399, 400 Covalent binding, 274, 384, 527 COX-1, 132 COX-2, 132 Creatinine, plasma, 274 Critical periods, 255 Cross resistance, 529 Crotalaria spectabilis, 323 Cyanide, 173, 223 Cycasin, 159, 160, 265 Cyclodiene insecticides, 222 Cyclohexamide, 265 Cyclooxygenases, 132 Cyclophosphamide, 122 Cyclosporine A, 123 CYP see Cytochrome P450 Cysteamine, 129 Cytochrome b5 , 115 Cytochrome P450 (CYP), 271, 272, 274, 277, 310, 318, 322, 323, 324 classi cation, 117 distribution, 116 CYP1, 119 CYP1A1, 119, 121 CYP1A1, induction, 191, 199 CYP1A2, 119, 121
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CYP1A2, induction, 192 CYP1B1, 119 CYP2, 119, 122 CYP2A6, 122 CYP2B, regulation, 191, 194 CYP2B6, 122 CYP2C, 122 CYP2C8, 122 CYP2C9, 122 CYP2C19, 122 CYP2D6, 182 CYP2E1, 123, 170 CYP2E1, regulation, 192, 197 CYP3A, regulation, 191, 196, 197 CYP3A4, 123, 323 CYP19, 310 evolution, 117 families, 119 123 induction, 123 multiplicity, 116 nomenclature, 117 puri cation, 116 reactions, 112, 123 128 Cytochrome P450 reductase, 114, 1320, 324 Cytotoxicity see Toxicity Cysteine conjugate -lyase see -Lyase Cytosol, 113 D DDE, 174, 204, 348 DDT, 57, 58, 137, 198, 204, 222, 307, 309, 348, 464, 465, 468 DDT dehydrochlorinase, 136 Deacetylation, 147 Dealkylation (O-, N-, and S-), 112, 124, 465 Debrisoquine, and polymorphisms, 182 Degradation abiotic, 465 biotic, 465 Dehalogenation, 112, 465 Dehydrogenation, 112 Delaney Amendment see Food, Drug and Cosmetics Act Demeton, 126 Dendrites, 280 Dermal irritation tests, 363 sensitization tests, 363 subchronic toxicity studies, 369 DES see Diethylstilbestrol Desulfuration, 112, 127
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