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60. Kuiken, T.; Fouchier, R. A. M.; Schutten, M.; Rimmelzwaan, G. F.; van Amerongen, G.; van Riel, D.; Laman, J. D.; de Jong, T.; van Doornum, G.; Lim, W.; Ling, A. E.; Chan, P. K. S.; Tam, J. S.; Zambon, M. C.; Gopal, R.; Drosten, C.; van der Werf, S.; Escriou, N.; Manuguerra, J.-C.; Stohr, K.; Peiris, J. S. M.; Osterhaus, A. D. M. E. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 2003, 362, 263 270. 61. Fouchier, R. A.; Kuiken, T.; Schutten, M.; van Amerongen, G.; van Doornum, G. J. J.; van den Hoogen, B.; Peiris, M.; Lim, W.; Stohr, K.; Osterhaus, A. D. M. E. Koch s postulates ful lled for SARS virus. Nature 2003, 423, 240. 62. Stadler, K.; Masignani, V.; Eickmann, M.; Becker, S.; Abrignani, S.; Klenk, H.-D.; Rappuoli, R. SARS beginning to understand a new virus. Nat. Rev. Microbiol. 2003, 1, 209 218. 63. Thiel, V.; Ivanov, K. A.; Putics, A.; Hertzig, T.; Schelle, B.; Bayer, S.; Weissbrich, B.; Snijder, E. J.; Rabenau, H.; Doerr, H. W.; Gorbalenya, A. E.; Ziebuhr, J. Mechanisms and enzymes involved in SARS coronavirus genome expression. J. Gen. Virol. 2003, 84, 2305 2315. 64. Li, W.; Moore, M. J.; Vasilieva, N.; Sui, J.; Wong, S. K.; Berne, M. A.; Somasundaran, M.; Sullivan, J. L.; Luzuriaga, K.; Greenough, T. C.; Choe, H.; Farzan, M. Angiotensinconverting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003, 426, 450 454. 65. Wong, S. K.; Li, W.; Moore, M. J.; Choe, H.; Farzan, M. A 193-amino acid fragment of the SARS coronavirus S protein ef ciently binds angiotensin-converting enzyme 2. J. Biol. Chem. 2004, 279, 3197 3201. 66. Sui, J.; Li, W.; Murakami, A.; Tamin, A.; Matthews, L. J.; Wong, S. K.; Moore, M. J.; St. Clair Tallarico, A.; Olurinde, M.; Choe, H.; Anderson, L. J.; Bellini, W. J.; Farzan, M.; Marasco, W. A. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 2536 2541. 67. Towler, P.; Staker, B.; Prasad, S. G.; Menon, S.; Tang, J.; Parsons, T.; Ryan, D.; Fisher, M.; Williams, D.; Dales, N. A.; Patane, M. A.; Pantoliano, M. W. ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J. Biol. Chem. 2004, 279, 17996 18007. 68. Anand, K.; Ziebuhr, J.; Wadhwani, P.; Mesters, J. R.; Hilgenfeld, R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science 2003, 300, 1763 1767. 69. Chou, K.-C.; Wei, D. Q.; Zhong, W.-Z. Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS. Biochem. Biophys. Res. Commun. 2003, 308, 148 151. 70. Yang, H.; Yang, M.; Liu, Y.; Lou, Z.; Zhou, Z.; Sun, L.; Mo, L.; Ye, S.; Pang, H.; Gao, G. F.; Anand, K.; Bartlam, M.; Hilgenfeld, R.; Rao, Z. The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 13190 13195. 71. Tanner, J. A.; Watt, R. M.; Chai, Y.-B.; Lu, L.-Y.; Lin, M. C.; Peiris, J. S. M.; Poon, L. L. M.; Kung, H.-F.; Huang, J.-D. The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 50 to 30 viral helicases. J. Biol. Chem. 2003, 278, 39578 39582.
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72. Xu, X.; Liu, Y.; Weiss, S.; Arnold, E.; Sara anos, S. G.; Ding, J. Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design. Nucleic Acids Res. 2003, 31, 7117 7130. 73. Barnard, D. L.; Hubbard, V. D.; Burton, J.; Smee, D. F.; Morrey, J. D.; Otto, M.-J.; Sidwell, R. W. Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and b-D-N 4-hydroxycytidine. Antiviral Chem. Chemother. 2004, 15, 15 22. 74. Balzarini, J.; Keyaerts, E.; Vijgen, L.; De Clercq, E.; Printsevskaya, S. S.; Preobrazhenskaya, M.; Van Ranst, M. Inhibitory activity of vancomycin, eremomycin and teicoplanin aglycon derivatives against feline and human ( i.e., SARS) coronaviruses. Abstracts of the 17th International Conference on Antiviral Research, Tucson, Arizona, USA, 2 6 May 2004. Antiviral Res. 2004, 62, A59, no. 78. 75. Balzarini, J.; Vijgen, L.; Keyaerts, E.; Van Damme, E.; Peumans, W.; De Clercq, E.; Egberink, H.; Van Ranst, M. Mannose-speci c plant lectins are potent inhibitors of coronavirus infection including the virus causing SARS. Abstracts of the 17th International Conference on Antiviral Research, Tucson, AZ, USA, 2 6 May 2004. Antiviral Res. 2004, 62, A76, no. 122. 76. Vijgen, L.; Keyaerts, E.; Van Damme, E.; Peumans, W.; De Clercq, E.; Balzarini, J.; Van Ranst, M. Antiviral effect of plant compounds of the Alliaceae family against the SARS coronavirus. Abstracts of the 17th International Conference on Antiviral Research, Tucson, AZ, USA, 2 6 May 2004. Antiviral Res. 2004, 62, A76, no. 123. 77. Cinatl, J.; Morgenstern, B.; Bauer, G.; Chandra, P.; Rabenau, H.; Doerr, H. W. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 2003, 361, 2045 2046. 78. He, M.-L.; Zheng, B.; Peng, Y.; Peiris, J. S. M.; Poon, L. L. M.; Yuen, K.Y.; Lin, M. C. M.; Kung, H.-F.; Guan, Y. Inhibition of SARS-associated coronavirus infection and replication by RNA interference. JAMA. 2003, 290, 2665 2666. 79. Neuman, B.; Stein, D.; Kroeker, A.; Kim, A.; Paulino, A.; Abma, J.; Bestwick, R.; Moulton, H.; Iversen, P.; Buchmeier, M. Rational mechanistic design of antisense morpholino oligomers to inhibit SARS coronavirus proliferation and growth. Abstracts of the 17th International Conference on Antiviral Research, Tucson, AZ, USA, 2 6 May 2004. Late Breakers, p. 11, LB-2. 80. Babcock, G. J.; Greenough, T. C.; Hernandez, H. J.; Thomas, W. D.; Lowy, I.; Graziano, R.; Finberg, R.; Subbarao, K.; Roberts, A.; Vogel, L.; Somasundaran, M.; Luzuriaga, K.; Ambrosino, D. M.; Sullivan, J. L. Human monoclonal antibodies against S glycoprotein neutralize SARS coronavirus (CoV) in mice. Abstracts of the 17th International Conference on Antiviral Research, Tucson, AZ, USA, 2 6 May 2004. Late Beakers, p. 12, LB-3. 81. Marti, J. F. B.; Jimenez, J. L.; Munoz-Fernandez, M. A. Pentoxifylline and severe acute respiratory syndrome (SARS): a drug to be considered. Med. Sci. Monit. 2003, 9, SR41 SR46. 82. Cinatl, J.; Morgenstern, B.; Bauer, G.; Chandra, P.; Rabenau, H.; Doerr, H. W. Treatment of SARS with human interferons. Lancet 2003; 362, 293 294. 83. Tan, E. L. C.; Ooi, E. E.; Lin, C.-Y.; Tan, H. C.; Ling, A. E.; Lim, B.; Stanton, L. W. Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs. Emerging Infect. Dis. 2004, 10, 581 586.
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