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14. Basler, C. F.; Wang, X.; Muhlberger, E.; Volchkov, V.; Paragas, J.; Klenk, H. D.; GarciaSastre, A.; Palese, P. The Ebola virus VP35 protein functions as a type I IFN antagonist. Proc. Natl. Acad. Sci. U.S.A. 2000, 97(22), 12289 12294. 15. Basler, C. F.; Mikulasova, A.; Martinez-Sobrido, L.; Paragus, J.; Muhlberger, E.; et al. The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3. J. Virol. 2003, 77, 7945 7956. 16. Zimring, J. C.; Goodbourn, S.; Offermann, M. K. Human herpesvirus 8 encodes an interferon regulatory factor (IRF) homolog that represses IRF-1-mediated transcription. J. Virol. 1998, 72, 701 707. 17. Barnard, P.; McMillan, N. A. The human papillomavirus E7 oncoprotein abrogates signaling mediated by interferon-a. Virology 1999, 259, 305 313. 18. Alcami, A.; Smith, G. L. Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species speci city. J. Virol. 1995, 69, 4633 4639. 19. Munoz-Jordan, J.; Sanchez-Burgos, G. G.; Laurent-Rolle, M.; Garcia-Sastre, A. Inhibition of interferon signaling by dengue virus. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 14333 14338. 20. Goodbourn, S.; Didcock, L.; Randall, R. E. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J. Gen. Virol. 2000, 81, 2341 2364. 21. Upton, C.; Mossman, K.; McFadden, G. Encoding of a homolog of the IFN-g receptor by myxoma virus. Science 1992, 258, 1369 1372. 22. Miller, D. M.; Rahill, B. M.; Lairmore, M. D.; Durbin, J. E.; Waldman, J. W.; et al. Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the JAK/STAT pathway. J. Exp. Med. 1998, 187, 675 683. 23. Miller, D. M.; Zhang, Y.; Rahill, B. M.; Waldman, W. J.; Sedmak, D. D. Human cytomegalovirus inhibits IFN-a-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-a signal transduction. J. Immunol. 1999, 162, 6107 6113. 24. Weihua, X.; Ramanujam, S.; Lindner, D. J.; Kudaravalli, R. D.; Freund, R.; et al. The polyoma virus T antigen interferes with interferon-inducible gene expression. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 1085 1090. 25. Didcock, L.; Young, D. F.; Goodbourn, S.; Randall, R. E. The V protein of simian virus 5 inhibits interferon signalling by targeting STAT1 for proteasome-mediated degradation. J. Virol. 1999, 73, 9928 9933. 26. Didcock, L.; Young, D. F.; Goodbourn, S.; Randall, R. E. Sendai virus and simian virus 5 block activation of interferon-responsive genes. J. Virol. 1999, 73, 3125 3133. 27. Yokosawa, N.; Kubota, T.; Fujii, N. Poor induction of interferon-induced 20 ,50 oligoadenylate synthetase (2-5 AS) in cells persistently infected with mumps virus is caused by decrease of STAT1-a. Arch. Virol. 1998, 143, 1985 1992. 28. Young, D. F.; Didcock, L.; Goodbourn, S.; Randall, R. E. Paramyxoviridae use distinct virus-speci c mechanisms to circumvent the interferon response. Virology 2000, 269, 383 390. 29. Leonard, G. T.; Sen, G. C. Effects of adenovirus E1A protein on interferon-signaling. Virology 1996, 224, 25 33.
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30. Rosmurduc, O.; Sirma, H.; Soussan, P.; Gordien, E.; Lebon, P.; et al. Inhibition of interferon-inducible MxA protein expression by hepatitus B virus capsid protein. J. Gen. Virol. 1999, 80, 1253 1262. 31. Brandt, T. A.; Jacobs, B. L. Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance Gene, E3L, are required for pathogenesis in a mouse model. J. Virol. 2001, 75(2), 850 856. 32. Carroll, K.; Elroy-Stein, O.; Moss, B.; Jagus, R. Recombinant vaccinia virus K3L gene product prevents activation of double-stranded-RNA-dependent initiation factor 2 alphaspeci c protein kinase. J. Biol. Chem. 1993, 268, 12837 12842. 33. Chang, H.-W.; Watson, J. C.; Jacobs, B. L. The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. U.S.A. 1992, 89, 4825 4829. 34. Davies, M. V.; Chang, H.-W.; Jacobs, B. L.; Kaufman, R. J. The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded-RNAdependent protein kinase by different mechanisms. J. Virol. 1993, 67, 1688 1692. 35. Davies, M. V.; Elroy-Stein, O.; Jagus, R.; Moss, B.; Kaufman, R. J. The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. J. Virol. 1992, 66, 1943 1950. 36. Dunlop, L. R.; Oehlberg, K. A.; Reid, J. J.; Avci, D.; Rosengard, A. M. Variola virus immune evasion proteins. Microbes Infect. 2003, 5, 1049 1056. 37. Fang, Z.-Y.; Limbach, K.; Tartaglia, J.; Hammonds, J.; Chen, X.; et al. Expression of vaccinia E3L and K3L genes by a novel recombinant canarypox HIV vaccine vector enhances HIV-1 psuedovirion production and inhibits apoptosis in human cells. Virology 2001, 291, 272 284. 38. Haig, D. M.; McInnes, C.; Thomson, J.; Wood, A.; Bunyan, K.; et al. The orf virus OV20.0L gene product is involved in interferon resistance and inhibits an interferoninducible, double-stranded RNA-dependent kinase. Immunology 1998, 93, 335 340. 39. Ho, C. K.; Shuman, S. Mutational analysis of vaccinia virus E3 protein de nes amino acid residues involved in E3 binding to double-stranded RNA. J. Virol. 1996. 70(4), 2611 2614. 40. Kibler, K. V.; Shors, T.; Perkins, K. B.; Zeman, C. C.; Banaszak, M. P.; et al. Doublestranded RNA is a trigger for apoptosis in vaccinia virus-infected cells. J. Virol. 1997, 71, 1992 2003. 41. Moss, B.; Shisler, J. L. Immunology 101 at poxvirus U: immune evasion genes. Semin. Immunol. 2001, 13, 59 66. 42. Shors, S. T.; Beattie, E.; Paoletti, E.; Tartaglia, J.; Jacobs, B. L. Role of vaccinia virus E3L and K3L gene products in rescue of VSV and EMCV from the effects of IFN-a. J. Interferon Cytokine Res. 1998, 18, 721 729. 43. Smith, V. P.; Alcami, A. Inhibition of interferons by ectromelia virus. J. Virol. 2002, 76(3), 1124 1134. 44. Xiang, Y.; Condit, R. C.; Vijaysri, S.; Jacobs, B. L.; Williams, B. R. G.; et al. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. J. Virol. 2002, 76, 5251 5259. 45. Sharp, T. V.; Schwemmle, M.; Jeffrey, I.; Laing, K.; Mellor, H.; et al. Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr
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