DISCOVERY AND DEVELOPMENT OF NEW ANTIVIRALS FOR SMALLPOX in .NET

Printing QR Code JIS X 0510 in .NET DISCOVERY AND DEVELOPMENT OF NEW ANTIVIRALS FOR SMALLPOX
DISCOVERY AND DEVELOPMENT OF NEW ANTIVIRALS FOR SMALLPOX
Scan QR-Code In .NET
Using Barcode Control SDK for Visual Studio .NET Control to generate, create, read, scan barcode image in VS .NET applications.
TABLE 14.11 Effect of Oral Pre- or Post-Single Dose Treatment with HDP-CDV or ODE-CDV on the Mortality of BALB/c Mice Inoculated with Cowpox Virus Mortality Number Percent 9/15 7/15 4/15 3/15 1/15 6/15 0/15 0/15 0/15 0/15 2/15 0/15 0/15 1/15 1/15 2/15 1/15 60 47 27 20 7 40 0 0 0 0 14 0 0 7 7 13 7
Painting QR-Code In Visual Studio .NET
Using Barcode encoder for Visual Studio .NET Control to generate, create QR Code JIS X 0510 image in .NET framework applications.
Treatment Placebo Saline 24 h Deionized H2O 24 h Day 5 CDV 30 mg/kg HDP 12.5 mg/kg ODE 10 mg/kg Day 3 CDV 30 mg/kg HDP 12.5 mg/kg ODE 10 mg/kg Day 1 CDV 30 mg/kg HDP 12.5 mg/kg ODE 10 mg/kg Day 1 CDV 30 mg/kg HDP 12.5 mg/kg ODE 10 mg/kg Day 3 CDV 30 mg/kg HDP 12.5 mg/kg ODE 10 mg/kg
QR Code JIS X 0510 Scanner In VS .NET
Using Barcode recognizer for .NET Control to read, scan read, scan image in VS .NET applications.
p <0.05 <0.05 <0.05 NS <0.001 <0.001 <0.001 <0.001 <0.05 <0.001 <0.001 <0.05 <0.05 <0.05 <0.05
Generating Barcode In .NET
Using Barcode generation for .NET Control to generate, create bar code image in Visual Studio .NET applications.
MDDa 12.2 2.8 11.9 2.9 11.5 2.5 10.3 2.1 11.0 0 11.7 3.9 10.0 1.4 21.0 0 15.0 0 11.5 2.1 16.0 0
Read Bar Code In Visual Studio .NET
Using Barcode decoder for .NET Control to read, scan read, scan image in .NET applications.
p NSb NS NS NS NS NS NS NS NS
Creating QR-Code In C#
Using Barcode printer for .NET Control to generate, create QR Code image in Visual Studio .NET applications.
MDD, mean day of death standard deviation. NS, not signi cant when compared to the combined placebo controls. Source: Adapted from Quenelle et al.54
QR Code Printer In .NET
Using Barcode encoder for ASP.NET Control to generate, create Quick Response Code image in ASP.NET applications.
ODE-CDV and persistence of therapeutic drug levels in critical organs of lung, liver, and kidney after a single oral dose of 10 mg/kg. This translates into oral dosing once or twice weekly instead of daily dosing. Since kidney exposure is reported to be low with oral HDP-CDV or ODE-CDV,53 one would anticipate reduced nephrotoxic adverse events. Oral HDP-CDV and ODE-CDV are at least equivalent to i.p. CDV in these studies and should be effective when used for prophylaxis, postexposure prophylaxis, or treatment for smallpox and other orthopoxviruses including monkeypox, which has become a problem due to unexpected outbreaks and increasing incidences of natural transmission. The compounds should also be effective in treating complications from vaccination with VV. Although both HDP-CDV and ODE-CDV appeared to have equivalent activity both in vitro and in vivo, the results of adsorption, distribution, metabolism, and
Encoding QR In Visual Basic .NET
Using Barcode generation for .NET framework Control to generate, create QR Code ISO/IEC18004 image in Visual Studio .NET applications.
REFERENCES
Drawing Code 128 Code Set A In .NET
Using Barcode generation for .NET Control to generate, create Code-128 image in Visual Studio .NET applications.
FIGURE 14.2 Effect of oral treatment with HDP-CDV, ODE-CDV, or CDV on pathogenesis of vaccinia virus IHD infection in mice.
Barcode Encoder In VS .NET
Using Barcode drawer for .NET Control to generate, create bar code image in .NET applications.
excretion studies have shown a preference for HDP-CDV and this compound should be evaluated in clinical studies in the next few months.
Make Barcode In VS .NET
Using Barcode generation for .NET Control to generate, create barcode image in Visual Studio .NET applications.
ACKNOWLEDGMENT The original work performed in the author s laboratory was supported by Contracts NO1-AI-85347 and NO1-AI-15439 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. The author gratefully acknowledges the excellent assistance of Jena L. Reeves in preparation of the manuscript for this chapter.
4-State Customer Barcode Encoder In .NET
Using Barcode creator for .NET Control to generate, create USPS OneCode Solution Barcode image in VS .NET applications.
REFERENCES
Create Barcode In Visual Basic .NET
Using Barcode drawer for Visual Studio .NET Control to generate, create bar code image in VS .NET applications.
1. Breman, J. G.; Henderson, D. A. Poxvirus delemmas monkeypox, smallpox, and biological terrorism. N. Engl. J. Med. 1998, 339, 556 559. 2. Breman, J. G.; Henderson, D. A. Diagnosis and management of smallpox. N. Engl. J. Med. 2002, 346, 1300 1308.
Create Code-128 In Java
Using Barcode generator for Java Control to generate, create Code-128 image in Java applications.
DISCOVERY AND DEVELOPMENT OF NEW ANTIVIRALS FOR SMALLPOX
UPC Symbol Creation In Java
Using Barcode drawer for Java Control to generate, create UPC Symbol image in Java applications.
3. Henderson, D. A. Bioterrorism as a public health threat. Emerging Infect. Dis. 1998, 4, 488 492. 4. Heymann, D. L.; Szczeniowski, M.; Esteves, K. Re-emergence of monkeypox in Africa: a review of the past six years. Br. Med. Bull. 1998, 54, 693 702. 5. O Toole, T. Smallpox: an attack scenario. Emerging Infect. Dis. 1999, 5, 540 546. 6. Hutin, Y. J.; Williams, R. J.; Malfait, P.; Pebody, R.; Loparev, V. N.; Ropp, S. L.; Rodriguez, M.; Knight, J. C.; Tshioko, F. K.; Khan, A. S.; Szczeniowski, M. V.; Esposito, J. J. Outbreak of human monkeypox, Democratic Republic of Congo, 1996 1997. Emerging Infect. Dis. 2001, 7, 434 438. 7. Bauer, D. J. The antiviral and synergic actions of isatin thiosemicarbazone and certain phenoxypyrimidines in vaccinia infection in mice. Br. J. Exp. Pathol. 1955, 36, 105 114. 8. Bauer, D. J.; Shef eld, F. W. Antiviral chemotherapeutic activity of isatin b-thiosemicarbazone in mice infected with rabbit-pox virus. Nature 1959, 184(Suppl 19), 1496 1497. 9. Boyle, J. J.; Haff, R. F.; Stewart, R. C. Evaluation of antiviral compounds by suppression of tail lesions in vaccinia-infected mice. Antimicrob. Agents Chemother 1966, 6, 536 539. 10. Bauer, D. J.; St. Vincent, L.; Kempe, C. H.; Downie, A. W. Prophylactic treatment of smallpox contacts with N-methylisatin b-thiosemicarbazone. Lancet 1963, ii, 494 496. 11. Bauer, D. J.; St Vincent, L.; Kempe, C. H.; Young, P. A.; Downie, A. W. Prophylaxis of smallpox with methisazone. Am. J. Epidemiol. 1969, 90, 130 145. 12. De Clercq, E.; De Somer, P. Effect of interferon, polyacrylic acid, and polymethacrylic acid on tail lesions on mice infected with vaccinia virus. Appl. Microbiol. 1968, 16, 1314 1319. 13. De Clercq, E.; Luczak, M.; Shugar, D.; Torrence, P. F.; Waters, J. A.; Witop, B. Effect of cytosine arabinoside, iododeoxyuridine, ethyldeoxyuridine, thiocyanatodeoxyuridine, and ribavirin on tail lesion formation in mice infected with vaccinia virus. Proc. Soc. Exp. Biol. Med. 1976, 151, 487 490. 14. De Clercq, E.; Holy, A.; Rosenberg, I.; Sakuma, T.; Balzarini, J.; Maudgal, P. C.. A novel selective broad-spectrum anti-DNA virus agent. Nature 1986, 323, 464 467. 15. De Clercq, E.; Sakuma, T.; Baba, M.; Pauwels, R.; Balzarini, J.; Rosenberg, I.; Holy, A. Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines. Antiviral Res. 1987, 8, 261 272. 16. De Clercq, E.; Holy, A.; Rosenberg, I. Ef cacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo. Antimicrob. Agents Chemother. 1989, 33, 185 191. 17. Naesens, L.; Snoeck, R.; Andrei, G.; Balzarini, J.; Neyts, J.; De Clercq, E. HPMPC (cidofovir), PMEA (adefovir) and related acyclic nucleoside phosphonate analogues: a review of their pharmacology and clinical potential in the treatment of viral infections. Antiviral Chem. Chemother. 1997, 8, 1 23. 18. De Clercq, E. Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections. Clin. Microbiol. Rev. 2001, 14, 382 397. 19. Neyts, J.; De Clercq, E. Ef cacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune de ciency (SCID) mice. J. Med. Virol. 1993, 41, 242 246.
GTIN - 13 Reader In VS .NET
Using Barcode reader for .NET Control to read, scan read, scan image in .NET applications.
Painting Barcode In .NET Framework
Using Barcode generator for ASP.NET Control to generate, create barcode image in ASP.NET applications.
Barcode Reader In Java
Using Barcode decoder for Java Control to read, scan read, scan image in Java applications.