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22. James, G. L.; Goldstein, J. L.; Brown, M. S.; Rawson, T. E.; Somers, T. C.; et al. Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. Science 1993, 260, 1937 1942. 23. Glenn, J. S.; Marsters, J. C. Jr.; Greenberg, H. B. Use of a prenylation inhibitor as a novel antiviral agent. J. Virol. 1998, 72, 9303 9306. 24. Lerner, E. C.; Qian, Y.; Blaskovich, M. A.; Fossum, R. D.; Vogt, A.; et al. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras Raf complexes. J. Biol. Chem. 1995, 270, 26802 26806. 25. Bordier, B. B.; Marion, P. L.; Ohashi, K.; Kay, M. A.; Greenberg, H. B.; et al. A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. J. Virol. 2002, 76, 10465 10472. 26. Marion, P. L.; Salazar, F. H.; Liittschwager, K.; Bordier, B. B.; Seeger, C.; et al. A Transgenic Mouse Lineage Useful for Testing Antivirals Targeting Hepatitis B Virus, Elsevier Science, New York, 2002, pp.197 209. 27. Liu, F.; Song, Y.; Liu, D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Therapy 1999, 6, 1258 1266. 28. Chang, J.; Sigal, L. J.; Lerro, A.; Taylor, J. Replication of the human hepatitis delta virus genome is initiated in mouse hepatocytes following intravenous injection of naked DNA or RNA sequences. J. Virol. 2001, 75, 3469 3473. 29. Bordier, B. B.; Ohkanda, J.; Liu, P.; Lee, S. Y.; Salazar, F. H.; et al. In vivo antiviral ef cacy of prenylation inhibitors against hepatitis delta virus. J. Clin. Invest. 2003, 112, 407 414. 30. Rice, C. M. Flaviviridae: the viruses and their replication. In Fields Virology, LippincottRaven Publications, Philadelphia, 1996, pp.931 959. 31. Glenn, J. S. Prenylation and virion morphogenesis. In The Unique Hepatitis Delta Virus, R.C. Landes Publishing, Austin, 1995, pp.83 93. 32. Farassati, F.; Yang, A. D.; Lee, P. W. Oncogenes in Ras signalling pathway dictate hostcell permissiveness to herpes simplex virus 1. Nat. Cell Biol. 2001, 3, 745 750. 33. Gower, T. L.; Graham, B. S. Antiviral activity of lovastatin against respiratory syncytial virus in vivo and in vitro. Antimicrob. Agents Chemother. 2001, 45, 1231 1237. 34. Ye, J.; Wang, C.; Sumpter, R. Jr.; Brown, M. S.; Goldstein, J. L.; et al. Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 15865 15870. 35. Bray, M. Pathogenesis and potential antiviral therapy of complications of smallpox vaccination. Antiviral Res. 2003, 58, 101 114. 36. Njoroge, F. G.; Doll, R. J.; Vibulbhan, B.; Alvarez, C. S.; Bishop, W. R.; et al. Discovery of novel nonpeptide tricyclic inhibitors of Ras farnesyl protein transferase. Bioorg. Med. Chem. 1997, 5, 101 113. 37. Dalton, M. B.; Fantle, K. S.; Bechtold, H. A.; DeMaio, L.; Evans, R. M.; et al. The farnesyl protein transferase inhibitor BZA-5B blocks farnesylation of nuclear lamins and p21ras but does not affect their function or localization. Cancer Res. 1995, 55, 3295 3304. 38. Sharma, S.; Kemeny, N.; Kelsen, D. P.; Ilson, D.; O Reilly, E.; et al. A Phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral
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administration, in patients with metastatic colorectal cancer refractory to 5- uorouracil and irinotecan. Ann. Oncol. 2002, 13, 1067 1071. 39. Farnsworth, C. C.; Gelb, M. H.; Glomset, J. A. Identi cation of geranylgeranyl-modi ed proteins in HeLa cells. Science 1990, 247, 320 322. 40. Sinensky, M.; Beck, L. A.; Leonard, S.; Evans, R. Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis. J. Biol. Chem. 1990, 265, 19937 19941. 41. Chang, F.-L.; Chen, P.-J.; Tu, S.-J.; Wang, C.-J.; Chen, D.-S. The large form of hepatitis d antigen is crucial for assembly of hepatitis d virus. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 8490 8494.
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