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1. Center for Food Safety and Applied Nutrition (CFSAN, US Food and Drug Administration) (2004). http://www.fda.gov/ohrms/dockets/ac/04/slides/2004-4045s2. htm (accessed 18 September 2008).
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2. Center for Food Safety and Applied Nutrition (CFSAN, US Food and Drug Administration) (2007). http://www.cfsan.fda.gov/ dms/furanexp/sld09.htm (accessed 18 September 2008). 3. IARC. (1995). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 63, Dry Cleaning, Some Chlorinated Solvents and Other Industrial Chemicals, pp. 394 407. 4. National Toxicology Program (NTP) (1993). Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies): NTP Technical Report No. 402, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, NC. 5. Center for Food Safety and Applied Nutrition (CFSAN), US Food and Drug Administration (2006). http://www.cfsan.fda.gov/ dms/furan.html (accessed 18 September 2008). 6. Swiss Federal Of ce of Public Health (SFOPH) (2004). Document submitted to the US FDA Docket, 2004N-0205: Furan in Food; Thermal Treatment. http://www. fda.gov/ohrms/dockets/default.htm (accessed 18 September 2008). 7. Zoller, O., Sager, F., Reinhard, H. (2007). Furan in food: headspace method and product survey. Food Addit. Contam., 24 (S1), 91 107. 8. Burka, L.T., Washburn, K.D., Irwin, R.D. (1991). Disposition of [14C]furan in the male F344 rat. J. Toxicol. Environ. Health, 34, 245 257. 9. Kedderis, G.L., Carfagna, M.A., Held, S.D., Batra, R., Murphy, J.E., Gargas, M.L. (1993). Kinetic analysis of furan biotransformation by F344 rats in vivo and in vitro. Toxicol. Appl. Pharmacol., 123, 274 282. 10. Parmar, D., Burka, L.T. (1993). Studies on the interaction of furan with hepatic cytochrome P-450. J. Biochem. Toxicol., 8, 1 9. 11. Kedderis, G.L., Held, S.D. (1996). Prediction of furan pharmacokinetics from hepatocyte studies: comparison of bioactivation and hepatic dosimetry in rats, mice, and humans. Toxicol. Appl. Pharmacol., 140, 124 130. 12. Kedderis, G.L. (1997). Extrapolation of in vitro enzyme induction data to human in vivo. Chem. Biol. Interact., 107, 109 121. 13. Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. (1994). Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Mol. Mutagen., 23 (1), 51 63. 14. Wilson, D.M., Goldsworthy, T.L., Popp, J.A., Butterworth, B.E. (1992). Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan. Environ. Mol. Mutagen., 19, 209 222. 15. Stich, H.F., Rosin, M.P., Wu, C.H., Powrie, W.D. (1981). Clastogenicity of furans found in food. Cancer Lett., 13, 89 95. 16. Lee, H., Bian, S.S., Chen, Y.L. (1994). Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test. Mutat. Res., 321, 213 218. 17. McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., Caspary, W.J. (1988). Responses of the L5178Y tk+/tk mouse lymphoma cell forward mutation assay. III: 72 coded chemicals. Environ. Mol. Mutagen., 12, 85 154.
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18. Mugford, C.A., Kedderis, G.L. (1996). Furan-mediated DNA double strand breaks in isolated rat hepatocytes. Fundam. Appl. Toxicol., 30 (1, Part 2), 128. 19. Mugford, C.A., Carfagna, M.A., Kedderis, G.L. (1997). Furan-mediated uncoupling of hepatic oxidative phosphorylation in Fisher-344 rats: an early event in cell death. Toxicol. Appl. Pharmacol., 144, 1 11. 20. Reynolds, S.H., Stowers, S.J., Patterson RM Maronpot, R.R., Aaronson, S.A., Anderson, MW (1987). Activated oncogenes in B6C3F1 mouse liver tumours: implications for risk assessment. Science, 237, 1309 1316. 21. Chen, L-J, Hecht, S.S., Peterson, L.A. (1995). Identi cation of cis-2-butene-1,4-dial as a microsomal metabolite of furan. Chem. Res. Toxicol., 8, 903 906. 22. Peterson, L.A., Naruko, K.C., Predercki, D.P. (2000). A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay. Chem. Res. Toxicol., 13 (7), 531 534. 23. Chen, L-J, Hecht, S.S., Peterson, L.A. (1997). Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan. Chem. Res. Toxicol., 10, 866 874. 24. Byrns, M.C., Predecki, D.P., Peterson, L.A. (2002). Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan. Chem. Res. Toxicol., 15 (3), 373 379. 25. Fransson-Steen, R., Goldsworthy, T.L., Kedderis, G.L., Maronpot, R.R. (1997). Furan-induced liver cell proliferation and apoptosis in female B6C3F1 mice. Toxicology, 118, 195 204.
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