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cancer: a study of a randomized population Br J Urol 1996;77:433 440 Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, Minasian LM, Ford LG, Lippman SM, Crawford ED, Crowley JJ, Coltman CA Jr Prevalence of prostate cancer among men with a prostatespeci c antigen level 40 ng per milliliter N Engl J Med 2004;350:2239 2246 Kundu SB, Grubb RL, Roehl KA, Antenor JA, Han M, Catalona WJ Delays in cancer detection using 2 and 4year screening intervals for prostate cancer screening with initial prostate speci c antigen less than 2 ng/ml J Urol 2005;173:1116 1120 Catalona WJ, Loeb S The PSA era is not over for prostate cancer Eur Urol 2005;48:541 545 Singh AB, Hsia S, Alaupovic P, et al The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men J Clin Endocrinol Metab 2002;87:136 143 Whitsel EA, Boyko EJ, Matsumoto AM, Anawalt BD, Siscovick DS Intramuscular testosterone esters and plasma lipids in hypogonadal men: a meta-analysis Am J Med 2001;111:261 269 Snyder PJ, Peachey H, Berlin JA, et al Effects of transdermal testosterone treatment on serum lipid and apolipoprotein levels in men more than 65 years of age Am J Med 2001;111:255 260 Dobs AS, Meikle AW, Arver S, Sanders SW, Caramelli KE, Mazer NA Pharmacokinetics, ef cacy, and safety of a permeation-enhanced testosterone transdermal system in comparison with bi-weekly injections of testosterone enanthate for the treatment of hypogonadal men J Clin Endocrinol Metab 1999;84:3469 3478 Zmuda JM, Cauley J , Kriska A, Glynn NW, Guptai JP, Kuller LH Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men: a 13-year follow-up of former Multiple Factor Intervention Trial participants Am J Epidemiol 1997;146:609 617 Kabakci G, Yildirir A, Can I, Unsal I, Erbas B Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in men undergoing coronary angiography Cardiology 1999;92: 221 225 Gooren LI The age-related decline of androgen levels in men: clinically signi cant Br J Urol 1996; 78:763 768 Gyllenborg J, Rasmussen SL, Borch-Johnsen K, Heitmann BL, Skakkebaek NE, Juul A Cardiovascular risk factors in men: the role of gonadal steroids and sex hormone-binding globulin Metabolism 2001;50: 882 888 English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, Channer KS Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms Eur Heart J 2000;21:890 894 Hak AE, Witteman JCM, de Jong FH, Geerlings MI, Hofman A, Pols HAP Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam Study J Clin Endocrinol Metab 2002;87:3632 3639 English KM, Steeds RP, Jones TH, Diver MJ, Channer KS Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebocontrolled study Circulation 2000;102:1906 1911 Anderson RA, Ludlam CA, Wu FC Haemostatic effects of supraphysiological levels of testosterone in normal men Thromb Haemost 1995;74: 693 697 Hajjar RR, Kaiser FE, Morley JE Outcomes of longterm testosterone replacement in older hypogonadal males: a retrospective analysis J Clin Endocrinol Metab 1997;82:3793 3796 Basaria S, Dobs AS Risks versus bene ts of testosterone therapy in elderly men Drugs Aging 1999;15: 131 142 The Endocrine Society Clinical bulletins in andropause: bene ts and risks of treating hypogonadism in the aging male Endocr Rep 2002;2:1 6 Morales A, Heaton JP, Carson CC 3rd Andropause: a misnomer for a true clinical entity J Urol 2000;163:705 712 Shabsigh A, Kang Y, Shabsigh R, et al Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism J Sex Med 2005;2:716 721 Morales A Androgen replacement therapy and prostate safety Eur Urol 2002;41:113 120 Jockenhoevel F Testosterone therapy, what, when and to whom Aging Male 2004;7:319 324 Bhasin S, Bremner WJ Emerging issues in androgen replacement therapy J Clin Endocrinol Metab 1997; 82:3 8 Stas SN, Anastasiadis AG, Fisch H, Benson MC, Shabsigh R Urologic aspects of andropause Urol 2003; 61:261 266 Schubert M, Minnemann T, et al Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism J Clin Endocrinol Metab 2004;89:5429 5434
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