PAMPA: 50 MODEL LIPID SYSTEMS in .NET

Creating DataMatrix in .NET PAMPA: 50 MODEL LIPID SYSTEMS
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D 2% C K) K) K) K) K) K) oy oy oy oy OP %S %S %S %S (SIN (SIN (SIN (SIN (SIN (SIN 20 35 68 PC 10 y y y y y So So So So So D O 10% 20% 35% 50% 74% 2%
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2% ) ) ) ) ) ) PC Soy Soy Soy Soy NK NK NK NK NK NK DO 10% 20% 35% 68% (SI y (SI y (SI y (SI y (SI y (SI P C So So So So So D O 10% 20% 35% 50% 74% 2%
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PERMEABILITY
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The more lipophilic molecules preferentially concentrate in the more lipophilic phase, leading to decreased permeabilities, according to the effect of the negative term in Eq (744), as the concentration of solute in the lower-lipophilicity phase decreases In the soy lecithin models, the lipid phases are systematically varied, with reference to a molecule of a particular lipophilicity The plots in Figs 731a c are orthogonally equivalent to the Kubinyi model type plots (Fig 719d), with each curve representing a particular molecule and the horizontal axis corresponding to varied lipid ratios Eq 744 applies and Figs 731a c may be interpreted as bilinear curves, for both sink and sinkless domains For example, the maximum permeability for most molecules occurs at about 20% wt/vol lecithin in dodecane For higher lecithin content, the negative term in Eq (744) dominates, causing the Pe values to decrease
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7754 Sink Condition to Offset the Attenuation of Permeability The preceding section treats the decrease in permeabilities with increasing lecithin content in dodecane in terms of shifting concentration distributions between a weak lipophilic domain (dodecane) and a stronger lipophilic domain (lecithin) Another view of this may be that at the molecular level, as the amount of phospholipid increases, the effects of electrostatic and H-bonding play a more prominent role in the transport process Generally, %R of the lipophilic molecules increases with increasing lecithin content, most dramatically in the case of lipophilic bases Such losses of compound to the membrane pose a challenge to the analysis of concentrations, which can be signi cantly diminished (to undetectable levels at times) in the aqueous compartments At the same time, the permeability drops to near vanishing values in 68% soy lecithin dodecane membranes Under these conditions, the permeabilities of the lipophilic bases and acids converge to similar low values, signi cantly departing from the expected values based on the octanol water lipophilicity scale (Table 74) and the pH partition hypothesis This excessive drug membrane binding would not be expected under in vivo conditions in the small intestine, due to the naturally occurring sink state There would be competing lipid environments in the receiving compartment (serum proteins, other membrane barriers, etc), and the solute-binding membrane would release a portion of the retained lipophilic molecules, resulting in a concomitant higher effective permeability The transport properties of the molecules in concentrated soy lecithin, Tables 712 714, do not adequately model the in vivo permeabilities reported by Winiwarter et al [56] (Table 74) The strategy to overcome this shortcoming of the model involves creating a model sink condition However, the use of BSA or other serum proteins, although easily effected, is not practical in high-throughput screening, since the UV absorption due to the proteins would render determination of the compound concentrations in the acceptor compartments by direct UV spectrophotometry nearly impossible in most cases Without knowledge of the concentration of sample in the acceptor compartment, the determination of %R would not be practical Some PAMPA practitioners, using BSA to create sink conditions, make the simplifying assumption that membrane retention is zero It is neither reason-
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