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200 1998 1999 2000 2001 2002 2003
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FIGURE 2.1 Dow Jones U.S. Biotechnology Stock Index (DJ_BTC) and Dow
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Jones U.S. Pharmaceutical Index (DJ_DRG) for 1998 to 2003.
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Source: Dow Jones & Company
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biotech bubble in 2000. It s true that in absolute monetary terms, venture capital investment in biotech and medical devices in 2002 was down from a high of $6.9 billion in 2000. However, prior to the bubble bursting, ven ture investment in Internet-related companies was booming and biotech companies raised $32 billion through initial public offerings (IPOs) and secondary offerings. Moreover, in relative terms, whereas venture investing in other areas fell 12 percent from 1998 to 2002, investment in biotech was up 70 percent during the same period. More recently, established pharmaceutical rms are investing in biotech in a frantic attempt to ll their pipelines with drugs, and this move is re ected in the investment com munity. Venture investing in biotechnology and medical devices totaled $4.7 billion in 2002, or about 22 percent of all venture capital investment that year, according to the MoneyTree survey by PricewaterhouseCoopers, Thomson Venture Economics, and the National Venture Capital Associa tion. This is the highest proportion in seven years, and represents a nearly fourfold increase in venture investing in biotech compared to 2000. In many ways, biotech appears poised to make a signi cant comeback as an investment vehicle and as a platform for innovation. However, the
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future of biotech depends on a social and political environment receptive to the technology. The future also depends on investment by the pharma ceutical, venture capital, academic, and government communities. In vestors and innovators in the eld will have to assess the promises of biotech relative to the established biotech markets, appreciate the chal lenges faced by the pharmaceutical industry, and understand the potential demand for biotech in secondary industries. This chapter presents the economics of pharmaceuticals to give the reader an understanding of the expensive process of bringing a new drug to market. It explores the role of biotech in helping pharmaceutical rms maintain innovation, competitiveness, and continued shareholder value, whether through working with biotech companies operating as indepen dent ventures, or by acquiring the biotech they need.
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The market activity in the years leading up to and following the biotech bubble in 2000 focused on new discoveries in genomics and their effect on pharmaceutical development, medical advances, and agricultural break throughs. However, the biotech industry predates the discovery of the dou ble helix structure of DNA or the sequencing of the human genome. As discussed here, the established biotech market includes the mass produc tion of amino acids, organic acids, polyhydroxyalkanoates (biodegradable plastics), microbial polysaccharides (gums), antibiotics, and enzymes. Ex amples of products within each market category, their applications, and the underlying technology used in their production are listed in Figure 2.2. Most of the products in the established biotech market rely at least partially on the growth of microbes (fermentation), including bacteria and fungi. Some products are synthesized primarily through chemical synthesis, the mixture of chemicals without the presence of microorganisms. This synthesis often depends on organic compounds (enzymes) that increase the rate and ef ciency of the chemical reactions, (enzymatic catalysis). Another approach used in the industry is biotransformation, the process by which compounds produced through chemical synthesis are transformed by mi croorganisms into the nal products. The converse operation, chemical processing, involves the chemical manipulation of compounds produced through the fermentation of microorganisms.
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Amino acids constitute a major biotech market, with applications ranging from pharmaceuticals and sweeteners to avor enhancers and food additives.
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Aspartate Cysteine Glutamic Acid Glycine Lysine Methionine Ascorbic Acid Citric Acid Gluconic Acid Lactic Acid PHB Fermentation Fermentation Fermentations
Food Additive, Sweetener, Pharmaceuticals Pharmaceuticals, Flavor Enhancer Flavor Enhancer Food Additive, Sweetener Feed Additive Feed Additive Food Additive, Pharmaceuticals Beverages, Food Preparation, Plasticiser Industrial, Food Additive, Pharmaceuticals Industrial, Food Additive, Pharmaceuticals Biodegradable Plastics, Medical Implants
Enzymatic Catalysis Chemical Synthesis Fermentation Chemical Synthesis Fermentation Chemical Synthesis Synthesis/Biotransformation Fermentation Fermentation Fermentation Fermentation