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limits are based on the best available information from industrial experience, from experimental human and animal studies, and, when possible, from a combination of the three. threshold limit value ceiling (TLV-C) This is the concentration that should not be exceeded even momentarily. For some substances (e.g., irritant gases), only one TLV category, the TLV-C, may be relevant. For other substances, two or three TLV categories may need to be considered. threshold limit value short-term exposure limit (TLV-STEL) This is the maximal concentration to which workers can be exposed for a period up to 15 minutes continuously without suffering from (1) irritation, (2) chronic or irreversible tissue change, or (3) narcosis of suf cient degree to increase accident proneness. threshold limit value time-weighted average (TLV-TWA) This is the TWA concentration for a normal 8-hour workday or 40-hour workweek to which nearly all workers may be exposed repeatedly day after day, without adverse effect. Timeweighted averages allow certain permissible excursions above the limit, provided that they are compensated by equivalent excursions below the limit during the workday. In some instances the average concentration is calculated for a workweek rather than for a workday. tolerance See adaptation to toxicants. Toxic Substances Control Act (TSCA) Enacted in 1976, the TSCA provides the EPA with the authority to require testing and to regulate chemicals, both old and new, entering the environment. It was intended to supplement sections of the Clean Air Act, the Clean Water Act, and the Occupational Safety and Health Act that already provide for regulation of chemicals. Manufacturers are required to submit information to allow the EPA to identify and evaluate the potential hazards of a chemical prior to its introduction into commerce. The act also provides for the regulation of production, use, distribution and disposal of chemicals. toxicant See poison. toxicokinetics See pharmacokinetics. toxicology Toxicology is de ned as that branch of science that deals with poisons (toxicants) and their effects; a poison is de ned as any substance that causes a harmful effect when administered, either by accident or design, to a living organism. There are dif culties in bringing a more precise de nition to the meaning of poison and in the de nition and measurement of toxic effect. The range of deleterious effects is wide and varies with species, gender, developmental stage, and so on, while the effects of toxicants are always dose dependent. toxin This is a toxicant produced by a living organism. Toxin should never be used as a synonym for toxicant. transport In toxicology this term refers to the mechanisms that bring about movement of toxicants and their metabolites from one site in the organism to another. Transport usually involves binding to either blood albumins or blood lipoproteins. ultimate carcinogen See carcinogen, ultimate. venom A venom is a toxin produced by an animal speci cally for the poisoning of other species via a mechanism designed to deliver the toxin to its prey. Examples include the venom of bees and wasps, delivered by a sting, and the venom of snakes, delivered by fangs.
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water pollution Water pollution is of concern in both industrialized and nonindustrialized nations. Chemical contamination is more common in industrialized nations, whereas microbial contamination is more important in nonindustrialized areas. Surface water contamination has been the primary cause for concern, but since the discovery of agricultural and industrial chemicals in groundwater, contamination of water from this source is also a problem. Water pollution may arise from runoff of agricultural chemicals, from sewage, or from speci c industrial sources. Agricultural chemicals found in water include insecticides, herbicides, fungicides, and nematocides; fertilizers, although less of a toxic hazard, contribute to such environmental problems as eutrophication. Other chemicals of concern include low molecular-weight halogenated hydrocarbons such as chloroform, dichloroethane, and carbon tetrachloride; polychlorinated biphenyls (PCBs); chlorophenols; 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD); phthalate ester plasticizers; detergents; and a number of toxic inorganics. xenobiotic A general term used to describe any chemical interacting with an organism that does not occur in the normal metabolic pathways of that organism. The use of this term in lieu of foreign compound, among others, has gained wide acceptance.
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