EXPOSURE CLASSES, TOXICANTS IN AIR, WATER, SOIL, DOMESTIC AND OCCUPATIONAL SETTINGS in VS .NET

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EXPOSURE CLASSES, TOXICANTS IN AIR, WATER, SOIL, DOMESTIC AND OCCUPATIONAL SETTINGS
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important commercially and represents about 90% of the total used. Use of asbestos has been extensive, especially in roo ng and insulation, asbestos cements, brake linings, electrical appliances, and coating materials. Asbestosis, a respiratory disease, is characterized by brosis, calci cation, and lung cancer. In humans, not only is there a long latency period between exposure and development of tumors but other factors also in uence the development of lung cancer. Cigarette smoking, for example, enhances tumor formation. Recent studies have shown that stomach and bowel cancers occur in excess in workers (e.g., insulation workers) exposed to asbestos. Other bers have been shown to cause a similar disease spectrum, for instance, zeolite bers.
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SUGGESTED READING Air Pollutants
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Costa, D. L. Air pollution. In Casarett and Doull s Toxicology: The Basic Science of Poisons, 6th ed., C. D. Klaassen, ed. New York: McGraw-Hill, 2001, pp. 979 1012. Holgate, S. T., J. M. Samet, H. Koren, and R. Maynard, eds. Air Pollution and Health. San Diego: Academic Press, 1999.
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Water and Soil Pollutants
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Abel, P. D., ed. Water Pollution Biology. London: Taylor and Francis, 1996. Hoffman, D. J., B. A. Rattner, G. A. Burton, and J. Cairns, eds. Handbook of Ecotoxicology, 2nd ed. Boca Raton: Lewis, 2002. Larson, S. J., P. D. Capel, and M. S. Majewski, eds. Pesticides in Surface Waters. Chelsea, MI: Ann Arbor Press, 1998.
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Occupational Toxicants
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Thorne, P. S. Occupational toxicology. In Casarett and Doull s Toxicology: The Basic Science of Poisons, 6th ed., C. D. Klaassen, ed. New York: McGraw-Hill, 2001, pp. 1123 1140. Doull, J. Recommended limits for occupational exposure to chemicals. In Casarett and Doull s Toxicology: The Basic Science of Poisons, 6th ed., C. D. Klaassen, ed. New York: McGrawHill, 2001, pp. 1155 1176.
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Classes of Toxicants: Use Classes
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INTRODUCTION
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As discussed in 1, use classes include not only chemicals currently in use but also the toxicological aspects of the development of new chemicals for commercial use, chemicals produced as by-products of industrial processes, and chemicals resulting from the use and/or disposal of chemicals. Because any use class may include chemicals from several different chemical classes, this classi cation is not suf cient for mechanistic considerations. It is, however, essential for an understanding of the scope of toxicology and, in particular, is essential for many applied branches of toxicology such as exposure assessment, industrial hygiene, public health toxicology and regulatory toxicology.
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5.2 5.2.1
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METALS History
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Although most metals occur in nature in rocks, ores, soil, water, and air, levels are usually low and widely dispersed. In terms of human exposure and toxicological signi cance, it is anthropogenic activities that are most important because they increase the levels of metals at the site of human activities. Metals have been used throughout much of human history to make utensils, machinery, and so on, and mining and smelting supplied metals for these uses. These activities increased environmental levels of metals. More recently metals have found a number of uses in industry, agriculture, and medicine. These activities have increased exposure not only to metal-related occupational workers but also to consumers of the various products. Despite the wide range of metal toxicity and toxic properties, there are a number of toxicological features that are common to many metals. Some of the more important aspects are discussed brie y in the following sections. For a metal to exert its toxicity, it must cross the membrane and enter the cell. If the metal is in a lipid soluble form such as methylmercury, it readily penetrates the membrane; when bound to proteins
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A Textbook of Modern Toxicology, Third Edition, edited by Ernest Hodgson ISBN 0-471-26508-X Copyright 2004 John Wiley & Sons, Inc.
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CLASSES OF TOXICANTS: USE CLASSES
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such as cadmium-metallothionein, the metal is taken into the cell by endocytosis; other metals (e.g., lead) may be absorbed by passive diffusion. The toxic effects of metals usually involve interaction between the free metal and the cellular target. These targets tend to be speci c biochemical processes and/or cellular and subcellular membranes.
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