TRANSPORT in VS .NET

Drawer Code 128C in VS .NET TRANSPORT
TRANSPORT
Code 128 Code Set A Recognizer In .NET
Using Barcode Control SDK for Visual Studio .NET Control to generate, create, read, scan barcode image in .NET applications.
For a chemical to be eliminated from the body at a site of elimination (i.e., kidney) that is distant from the site of storage (i.e., adipose tissue) or toxicity (i.e., brain), the chemical must be transported from the site of origin to the site of elimination. Chemicals are transported to the site of elimination largely via the circulatory system. Suf ciently water-soluble chemicals can freely dissolve into the aqueous component of blood and be transported by both diffusion and blood circulation to sites of elimination. With decreasing water solubility and increasing lipid solubility, chemicals are less likely to freely diffuse into blood and extraction of these chemicals from sites of toxicity or storage can be more challenging. These materials generally associate with transport proteins in the blood, which either contain binding sites for chemical attachment or lipophilic cores (lipoproteins) into which lipophilic chemicals can diffuse. The blood contains various transport proteins that are typically suited for the transport of speci c endogenous chemicals. These include albumin, sex steroid-binding globulin, and lipoproteins. Often xenobiotics can utilize these proteins, particularly the nonspeci c transporters, to facilitate mobilization and transport in the aqueous environment of the blood. At the site of elimination, xenobiotics may diffuse from the transport protein to the membranes of the excretory organ, or the transport protein may bind to surface receptors on the excretory organ, undergo endocytosis and intracellular processing, where the xenobiotic is released and undergoes processing leading to elimination.
Code 128 Generator In .NET
Using Barcode creator for Visual Studio .NET Control to generate, create Code 128 Code Set B image in VS .NET applications.
RENAL ELIMINATION
Decode Code 128 Code Set B In .NET Framework
Using Barcode recognizer for Visual Studio .NET Control to read, scan read, scan image in VS .NET applications.
The kidneys are the sites of elimination of water-soluble chemicals that are removed from the blood by the process of reverse ltration. Two characteristics are primarily responsible for determining whether a chemical will be eliminated by the kidneys: size and water solubility. Size. The reverse ltration process requires that chemicals to be removed from the blood are able to pass through 70 to 100 A pores. As a rule, chemicals having a molecular mass of less than 65,000 are suf ciently small to be subject to reverse ltration. Water Solubility. Non-water-soluble chemicals will be transported to the kidneys in association with transport proteins. Thus, in association with these proteins, the chemicals will not be able to pass through the pores during reverse ltration. Lipophilic chemicals are generally subject to renal elimination after they
Bar Code Creation In .NET Framework
Using Barcode generator for .NET Control to generate, create bar code image in .NET applications.
ELIMINATION OF TOXICANTS
Decode Barcode In .NET Framework
Using Barcode recognizer for VS .NET Control to read, scan read, scan image in .NET applications.
have undergone hydroxylation or conjugation reactions ( 7) in the liver or elsewhere. Blood is delivered to the human kidney by the renal artery. Blood ows to the kidneys of the adult human at a rate of roughly 1 L/min. The adult human kidney contains approximately 1 million functional units, called nephrons, to which the blood is delivered for removal of solutes. Collected materials are excreted from the body in the urine. Blood entering the nephron passes through a network of specialized capillaries called the glomerulus (Figure 10.1). These capillaries contain the pores through which materials to be eliminated from the blood pass. Blood in the capillaries is maintained under high positive pressure from the heart coupled with the small diameter of the vessels. As a result these suf ciently small solutes and water are forced through the pores of the glomerulus. This ltrate is collected in the glomerular (or Bowman s) capsule in which the glomerulus is located (Figure 10.1). Included in this ltrate are water, ions, small molecules such as glucose, amino acids, urate, and foreign chemicals. Large molecules such as proteins and cells are not ltered and are retained in the blood. Following glomerular ltration, molecules important to the body are re-absorbed from the ltrate and returned to the blood. Much of this re-absorption occurs in the proximal tubules (Figure 10.1). Cells lining the proximal tubules contain ngerlike projections that extent into the lumen of the tubule. This provides an expanse of cell surface area across which water and ions can diffuse back into the cells and, ultimately, be returned to the blood. The proximal tubules also contain active transport proteins that recover small molecules such as glucose and amino acids from the ltrate. From the proximal tubules, the ltrate passes through the Loop of Henle. Signi cant water
Paint Code-128 In C#
Using Barcode printer for .NET framework Control to generate, create ANSI/AIM Code 128 image in .NET framework applications.
Code 128 Code Set A Creation In .NET
Using Barcode encoder for ASP.NET Control to generate, create Code 128A image in ASP.NET applications.
Paint UPC-A Supplement 5 In .NET
Using Barcode drawer for .NET framework Control to generate, create UPCA image in .NET applications.
Bar Code Creation In .NET
Using Barcode maker for Visual Studio .NET Control to generate, create bar code image in .NET framework applications.
EAN13 Generator In Visual Studio .NET
Using Barcode creation for ASP.NET Control to generate, create EAN13 image in ASP.NET applications.
Draw GS1 - 12 In Visual Basic .NET
Using Barcode maker for Visual Studio .NET Control to generate, create UPC Symbol image in Visual Studio .NET applications.
Code 128 Encoder In VB.NET
Using Barcode generator for .NET Control to generate, create Code128 image in VS .NET applications.
Paint Code 39 Full ASCII In C#
Using Barcode drawer for VS .NET Control to generate, create Code 3/9 image in Visual Studio .NET applications.