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1. Borio, L.; Inglesby, T.; Peters, C. J.; Schmaljohn, A. L.; Hughes, J. M.; Jahrling, P. B.; Ksiazek, T.; Johnson, K. M.; Meyerhoff, A.; O Toole, T.; Ascher, M. S.; Bartlett, J.; Breman, J. G.; Eitzen, E. M.; Hamburg, M.; Hauer, J.; Henderson, D. A.; Johnson, R. T.; Kwik, G.; Layton, M.; Lillibridge, S.; Nabel, G. J.; Osterholm, M. T.; Perl, T. M.; Russell, P.; Tonat, K. Hemorrhagic fever viruses as biological weapons medical and public health management. JAMA 2002, 287, 2391 2405. 2. (a) Center for Biosecurity of UPMC, Viral Hemorrhagic Fevers Fact Sheet (2003), http://www.upmc-biosecurity.org/pages/agents/vhf_facts.html (accessed April 14, 2004). (b) Centers for Disease Control and Prevention, Viral Hemorrhagic Fevers (2003), http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/ vhf.htm (accessed April 14, 2004). 3. Alibek, K.; Handelman, S. Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World, Told from the Inside by the Man Who Ran It, Random House, New York, 1999, p. 319. 4. Miller, J.; Engelberg, S.; Broad, W. Germs: Biological Weapons and America s Secret War, Simon & Schuster, New York, 2001, p. 382. 5. Johnson, E.; Jaax, N.; White, J.; Jahrling, P. Lethal experimental infections of rhesusmonkeys by aerosolized Ebola-virus. Int. J. Exp. Pathol. 1995, 76, 227 236. 6. References 16 and 19 of Reference 1. 7. Stephenson, E. H.; Larson, E. W.; Dominik, J. W. Effect of environmental factors on aerosol-induced Lassa virus infection. J. Med. Virol. 1984, 14, 295 303.
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8. Kenyon, R. H.; Mckee, K. T.; Zack, P. M.; Rippy, M. K.; Vogel, A. P.; et al. Aerosol infection of rhesus macaques with Junin virus. Intervirology 1992, 33, 23 31. 9. Jackson, R. J.; Ramsay, A. J.; Christensen, C. D.; Beaton, S.; Hall, D. F.; Ramshaw, I. A. Expression of mouse interleukin-4 by recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. J. Virol. 2001, 75, 1205 1210. 10. Center for Nonproliferation Studies, Chemical and Biological Weapons: Possession and Programs Past and Present (2002), http://cns.miis.edu/research/cbw/possess.htm (accessed 14 April 2004). 11. Leroy, E. M.; Rouquet, P.; Formenty, P.; Souquiere, S.; Kilbourne, A.; Froment, J.-M.; Bermejo, M.; Smit, S.; Karesh, W.; Swanepoel, R.; Zaki, S. R.; Rollin, P. E. Multiple Ebola transmission events and rapid decline of central African wildlife. Science 2004, 303, 387 390. 12. (a) Geisbert, T. W.; Hensley, L. E.; Larsen, T.; Young, H. A.; Reed, D. S.; Geisbert, J. B.; Scott, D. P.; Kagan, E.; Jahrling, P. B.; Davis, K. J. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: Evidence that hemorrhage is not a direct effect of virusinduced cytolysis of endothelial cells. Am. J. Pathol. 2003, 163, 2347 2370. (b) Peterson, A. T.; Bauer, J. T.; Mills, J. N. Ecologic and geographic distribution of lovirus disease. Emerging Infect. Dis. 2004, 10, 40 47. 13. Steinberg, D. Antiterror agenda promotes Ebola vaccine and immunotherapy. Scientist 2002, 16 32 33. 14. (a) Andrei, G.; De Clercq, E. Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993, 22, 45 75. (b) Bray, M.; Paragas, J. Experimental therapy of lovirus infections. Antiviral Res. 2002, 54, 1 17. 15. Nabel, G. J. Vaccine for AIDS and Ebola virus infection. Virus Res. 2003, 92, 213 217. 16. Feldmann, H.; Jones, S.; Klenk, H.-D.; Schnittler, H.-J. Ebola virus: from discovery to vaccine. Nat. Rev. Immunol. 2003, 3, 677 685. 17. Nelson, R. Novel Ebola vaccine begins rst human trials. Lancet 2003, 362, 1815. 18. Barrientos, L. G.; O Keefe, B. R.; Bray, M.; Sanchez, A.; Gronenborn, A. M.; Boyd, M. R. Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus. Antiviral Res. 2003, 58, 47 56. 19. De Clercq, E. Antiviral activity spectrum and target of action of different classes of nucleoside analogs. Nucleosides Nucleotides 1994, 13, 1271 1295. 20. Bray, M.; Driscoll, J.; Huggins, J. W. Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor. Antiviral Res. 2000, 45, 135 147. 21. Huggins, J.; Zhang, Z.-X.; Bray, M. Antiviral drug therapy of lovirus infections: S-adenosylhomocysteine hydrolase inhibitors inhibit Ebola virus in vitro and in a lethal mouse model. J. Infect. Dis. 1999, 179 (Suppl. 1), S240 S247. 22. Bray, M.; Raymond, J. L.; Geisbert, T. W.; Baker, R. O. 3-Deazaneplanocin A induces massively increased interferon-a production in Ebola virus-infected mice. Antiviral Res. 2002, 55, 151 159. 23. Basler, C. F.; Wang, X.; Muhlberger, E.; Volchkov, V.; Paragas, J.; Klenk, H.-D; GarciaSastre, A.; Palese, P. The Ebola virus VP35 protein functions as a type I IFN antagonist. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 12289 12294.
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