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20. Baker, R. O.; Bray, M.; Huggins, J. W. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003, 57, 13 23. 21. Kern, E. R.; Hartline, C.; Harden, E.; Keith, K.; Rodriguez, N.; Beadle, J. R.; Hostetler, K. Y. Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir. Antimicrob. Agents Chemother. 2002, 46, 991 995. 22. Bray, M.; Martinez, M.; Smee, D. F.; Kefauver, D.; Thompson, E.; Huggins, J. W. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J. Infect. Dis. 2000, 181, 10 19. 23. Bray, M.; Martinez, M.; Kefauver, D.; West, M.; Roy, C. Treatment of aerosolized cowpox virus infection in mice with aerosolized cidofovir. Antiviral Res. 2002, 54, 129 142. 24. Smee, D. F.; Bailey, K. W.; Wong, M. H.; Sidwell, R. W. Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir. Antiviral Res. 2000, 47, 171 177. 25. Smee, D. F.; Bailey, K. W.; Sidwell, R. W. Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir. Antiviral Chem. Chemother. 2001, 12, 71 76. 26. Quenelle, D. C.; Collins, D. J.; Kern, E. R. Ef cacy of multiple- or single-dose cidofovir against vaccinia and cowpox virus infections in mice. Antimicrob. Agents Chemother. 2003, 47, 3275 3280. 27. Huggins, J. W.; Martinez, M. J.; Hartmann, C. J.; Hensley, L. E.; Jackson, D. L.; Refoeven, D. F.; Kuksh, D. A.; Lawson, T.; Miller, D. M.; Mucker, E. A.; Shamblin, J. D.; Tate, M. K.; Whitehour, L. A.; Swiers, S. H.; Jahrling, P. B.. Successful cidofovir treatment of smallpox-like diseases in variola and monkeypox primate models. Antiviral Res. 2004, 62, A57. 28. Cundy, K. C.; Bidgood, A. M.; Lynch, G.; Shaw, J. P.; Grif n, L.; Lee, W. A. Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats. Drug Metab. Dispos. 1996, 24, 745 752. 29. Cundy, K. C.; Li, Z. H.; Hitchcock, M. J.; Lee, W. A. Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug. Drug Metab. Dispos. 1996, 24, 738 744. 30. Kern, E. R. In vitro activity of potential anti-poxvirus agents. Antiviral Res. 2003, 57, 35 40. 31. Safrin, S.; Cherrington, J.; Jaffe, H. S. Clinical uses of cidofovir. Rev. Med. Virol. 1997, 7, 145 156. 32. De Clercq, E. Cidofovir in the therapy and short-term prophylaxis of poxvirus infections. Trends Pharmacol. Sci. 2002, 23, 456 458. 33. Smee, D. F.; Sidwell, R. W. Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 20 - uoro-arabinofuranosyl nucleosides. Nucleosides Nucleotides Nucleic Acids 2004, 23, 375 383. 34. Barditch-Crovo, P.; Toole, J.; Hendrix, C. W.; Cundy, K. C.; Ebeling, D.; Jaffe, H. S.; Lietman, P. S. Anti-human immunode ciency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl) phosphonylmethoxyethyl]adenine) in HIV-infected patients. J. Infect. Dis. 1997, 176, 406 413. 35. Neyts, J.; De Clercq, E. Ef cacy of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine for treatment of vaccinia virus (orthopoxvirus) infections in mice. Antimicrob. Agents Chemother. 2001, 45, 84 87.
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36. Smee, D. F.; Bailey, K. W.; Sidwell, R. W. Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug. Antiviral Res. 2002, 54, 113 120. 37. De Clercq, E. In search of a selective antiviral chemotherapy. Clin. Microbiol. Rev. 1997, 10, 674 693. 38. De Clercq, E. Cidofovir in the treatment of poxvirus infections. Antiviral Res. 2002b, 55, 1 13. 39. Keith, K. A.; Hitchcock, M. J.; Lee, W. A.; Holy, A.; Kern, E. R. Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrob. Agents Chemother. 2003, 47, 2193 2198. 40. Smee, D. F.; Bailey, K. W.; Sidwell, R. W. Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir. Antiviral Chem. Chemother. 2000, 11, 303 309. 41. Smee, D. F.; Bailey, K. W.; Wong, M. H.; Sidwell, R. W. Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice. Antiviral Res. 2001, 52, 55 62. 42. Roy, C. J.; Baker R.; Washburn, K.; Bary, M. Aerosolized cidofovir is retained in the respiratory tract and protects mice against intranasal cowpox virus challenge. Antimicrob. Agents Chemother. 2003, 47, 2933 2937. 43. Snoeck, R.; Holy, A.; Dewolf-Peeters, C.; Van Den Oord, J.; De Clercq, E.; Andrei, G. Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures. Antimicrob. Agents Chemother. 2002, 46, 3356 3361. 44. Hostetler, K. Y.; Beadle, J. R.; Kini, G. D.; Gardner, M. F.; Wright, K. N.; Wu, T. H.; Korba, B. A. Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro. Biochem. Pharmacol. 1997, 53, 1815 1822. 45. Hostetler, K. Y.; Rybak, R. J.; Beadle, J. R.; Gardner, M. F.; Aldern, K. A.; Wright, K. N; Kern, E. R. In vitro and in vivo activity of 1-O-hexadecylpropanediol-3-phosphoganciclovir and 1-O-hexadecylpropanediol-3-phospho-penciclovir in cytomegalovirus and herpes simplex virus infections. Antiviral Chem. Chemother. 2001, 12, 61 70. 46. Hostetler, K. Y.; Beadle, J. R.; Hornbuckle, W. E.; Bellezza, C. A.; Tochkov, I. A.; Cote, P. J.; Gerin, J. L.; Korba, B. E.; Tennant, B. C. Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob. Agents Chemother. 2000, 44, 1964 1969. 47. Huggins, J. W.; Baker, R. O.; Beadle, J. R.; Hostetler, K. Y. Orally active ether lipid prodrugs of cidofovir for the treatment of smallpox. Antiviral Res. 2002, 53, A66. 48. Buller, R. M.; Owens, G.; Schriewer, J.; Melman, L.; Beadle, J. R.; Hostetler, K. Y. Ef cacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model. Virology 2004, 318, 474 481. 49. Beadle, J. R.; Hartline, C. B.; Aldern, K. A.; Rodriguez, N.; Harden, E.; Kern, E. R.; Hostetler, K. Y. Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro. Antimicrob. Agents Chemother. 2002, 46, 2381 2386. 50. Hartline, C. B.; Gustin, K. M.; Wan, W. B.; Ciesla, S. L.; Beadle, J. R.; Hostetler, K. Y.; Kern, E. R. Ether lipid ester prodrugs of acyclic nucleoside phosphonates: Activity against adenovirus replication in vitro. J. Infect. Dis. 2005, 191, 396 399.
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