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21. Zhang, N.; Chen, H. M.; Koch, V.; Schmitz, H.; Liao, C. L.; et al. Ring-expanded ( fat ) nucleoside and nucleotide analogues exhibit potent in vitro activity against Flaviviridae NTPase/helicases, including those of West Nile virus, hepatitis C virus and Japanese encephalitis virus. J. Med. Chem. 2003, 46, 4149 4164. 22. Borowski, P.; Niebuhr, A.; Mueller, O.; Bretner, M.; Felczak, K.; et al. Puri cation and characterization of West Nile virus nucleoside triphosphatase (NTPase)/helicase: evidence for dissociation of the NTPase and helicase activities of the enzyme. J. Virol. 2001, 75, 3220 3229. 23. Borowski, P.; Lang, M.; Haag, A.; Schmitz, H.; Choe, J.; et al. Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme. Antimicrob. Agents Chemother. 2002, 46, 1231 1239. 24. Tai, C. L.; Chi, W. K.; Chen, D. S.; Hwang, L. H. The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J. Virol. 1996, 70, 8477 8484. 25. Diana, G. D.; Bailey, T. R. Compounds, composition and methods for treatment of hepatitis C. US Patent No. 6,127,384, 1996. 26. Deluca, M. R.; Kervin, S. M. The para-toluenosulfonic acid promoted synthesis of 2-substituted benzoxazoles and benzimidazoles from diacylated precursors. Tetrahedron 1996, 53, 457 464. 27. Phoon, C. W.; Ng, Y. P.; Ting, A. E.; Yeo, S. L.; Sim, M. M. Biological evaluation of hepatitis C virus helicase inhibitors. Bioorg. Med. Chem. Lett. 2001, 11, 1647 1650. 28. Borowski, P.; Kuhl, R.; Laufs, R.; Schulze zur Wiesch, J.; Heiland, M. Identi cation and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus. J. Clin. Virol. 1999, 13, 61 69. 29. Borowski, P.; Niebuhr, A.; Schmitz, P.; Hosmane, R. S.; Bretner, M.; et al. NTPase/ helicase of Flaviviridae: inhibitors and inhibition of the enzyme. Acta Biochim. Pol. 2002, 49, 597 614. 30. Ingallinella, P.; Altamura, S.; Bianchi, E.; Taliani, M.; Ingenito, R.; et al. Potent peptide inhibitors of HCV NS3 protease are obtained by optimizing the cleavage products. Biochemistry 1998, 37, 8906 8914. 31. Leung, D.; Schroder, K.; White, H.; Fang, N. X.; Stoermer, M.; et al. Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates and inhibitors. J. Biol. Chem. 2001, 276, 45762 45771. 32. Wu, S. F.; Lee, C. J.; Liao, C. L.; Dwek, R.; Zitzmann, N.; et al. Antiviral effects of an iminosugar derivative on avivirus infections. J. Virol. 2002, 76, 3596 3604. 33. Lindenbach, B. D.; Rice, C. M. Trans-complementation of yellow fever virus NS1 reveal a role in early RNA replication. J. Virol. 1997, 71, 9608 9617. 34. Crotty, S.; Cameron, C.; Andino, R. Ribavirin s antiviral mechanism of action: lethal mutagenesis J. Mol. Med. 2002, 80, 86 95. 35. Jordan, I.; Briese, T.; Fischer, N.; Yiu-Nam, J.; Lipkin, W. I. Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells. J. Infect. Dis. 2000, 182, 1214 1217. 36. Morrey, J. D.; Smee, D. F.; Sidwell, R. W.; Tseng, C. Identi cation of active antiviral compounds against a New York isolate of West Nile virus. Antiviral Res. 2002, 55, 107 116.
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