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22. U.S. Food and Drug Administration (1997) Centre for Food Safety and Applied Nutrition, Ethyl Carbamate Preventative Action Manual. http://www.cfsan.fda. gov/ frf/ecaction.html. 23. Walker, R. (1990). Nitrates, nitrites and N-nitrosocompounds: a review of the occurrence in food and diet and the toxicological implications. Food Additives and Contaminants, 7, 717 768. 24. Lathia, D., Blum, A. (1989). Role of vitamin E as nitrite scavenger and Nnitrosamine inhibitor: a review. International Journal of Vitamin and Nutrition Research, 59, 430 438. 25. Fiddler, W., Pensabene, J.W., Piotrowski, E.G., Phillips, J.G., Keating, J., Mergens, W.J., Newmark, H.L. (1978). Inhibition of formation of volatile nitrosamines in fried bacon by the use of cure-solubilized a-tocopherol. Journal of Agriculture and Food Chemistry, 26 (3), 653 656. 26. EFSA Scienti c Panel on Biological Hazards (2003). Opinion of the scienti c panel on biological hazards on the request from the commission related to the effects of nitrites/nitrates on the microbiological safety of meat products. The EFSA Journal, 14, 1 31. 27. Hartwig, A., Pelzer, A., Burnouf, D., Tit ca, H., Delinc e, H., Briviba, K., Soika, C., Hodapp, C., Raul, F., Miesch, M., Werner, D., Horvatovich, P., Marchioni, E. (2007). Toxicological potential of 2-alkylcyclobutanones speci c radiolytic products in irradiated fat-containing food in bacteria and human cell lines. Food and Chemical Toxicology, 45, 2581 2591. 28. McNeal, T.P., Nyman, P.J., Diachenko, G.W., Holli eld, H.C. (1993). Survey of benzene in foods by using headspace concentration techniques and capillary gas chromatography. Journal of AOAC International, 76, 1213 1219. 29. Pedersen, J.I. (2006). Composition of post trans margarines (abstract). Fats and health update on dietary phytosterols, trans fatty acids and conjugated linoleic acids. DGF Meeting, October 2006, Frankfurt, pp. 19 20.
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Accepted Daily Intake (ADI) 696 Acenaphthene 245 Acenaphthylene 245 Acetaldehyde 60 Acetol (3-hydroxyacetone) 200 Acid-Hydrolysed Vegetable Proteins (acid-HVP) 177, 203, 539, 541, 567 Acrolein 51 acceptable daily intake (ADI) 65 acute dermal LD50 62 acute oral LD50 62 ambient air 53, 64 analysis methods 55 59 chemical and physical properties 56 emission 51, 53 Environmental Protection Agency (EPA) 51 formation 51 herbicide 51 inhalation toxicity 62 mechanisms of formation 59 62 occurrence in foods 53 55 precursors 53 toxicity 51, 62 65 use 51
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Acrylaldehyde, see Acrolein Acrylamide 10, 23, 566, 582, 698 agronomical factors 32, 33 analysis 30 brochures 39, 41 CIAA Acrylamide Toolbox 16, 31, 39, 40, see also CIAA Codex Code of Practice 41 exposure estimates 35, 37 FAO/WHO consultation 33 haemoglobin adduct 25, 39 health risks 37 39 JECFA evaluation 38 JIFSAN database 40 mechanisms of formation 26 30 occurrence in foods 24 25 polymer 23 railway tunnel accident 23 reduction in food 31 33, 41 Acrylaway 32 Acrylic acid 59, 61 Acute Reference Dose (ARfD) 585 Adiabatic heating 451 Adrenal Medulla lesions 129
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Process-Induced Food Toxicants: Occurrence, Formation, Mitigation, and Health Risks, Edited by Richard H. Stadler and David R. Lineback Copyright 2009 by John Wiley & Sons, Inc.
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712 Advanced Glycation Endproducts (AGEs) 151, 215, 702 analysis 223 227 exposure 228 229 formation 218 223 health risks 229 232 historical perspective 215 218 mitigation 227 228 Agency for Toxic Substances and Disease Registry 65 AGE-RAGE interactions 230 Agmatine 323 Alcoholic beverages 140 143, 297, 373, see also Beer; Wine Aldehyde , -unsaturated 158 reactive 155, 701 Strecker, see Strecker aldehyde Alfalfa seeds 513 2-Alkylcyclobutanone 393 2-Alkylcyclobutanones 705 Allyl alcohol 196 Almonds, roasted 138 Alzheimer s disease 340, 702 Amadori compound 27, 220, 221, 511, 512, 515, see also Amadori rearrangement product Amadori compound, protein bound 221 Amadori rearrangement 218 Amadori rearrangement product (ARP) 150 151, 647 American Beverage Association 432 Ames Salmonella typhimurium mutagenesis assay 82, 88, 122, 131, 157, 288, 405 Amino acids 648 cross-linked 222, 475, 480 D-isomers 475, 482 Amino acid decarboxylase activity 324 -Aminoalanine 480 2-Amino-1,4-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-1) 77 2-Amino-1-dimethyl-5H-pyrido [4,3-b]indole (Trp-P-2) 77 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) 78 2-Amino-3,4,8-trimethylimidazo [4,5-f]quinoxaline (4,8-DiMeIQx) 78 2-Amino-3,8-dimethylimidazo[4,5f]quinoxaline (8-MeIQx) 78
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