PERMEABILITY LIPOPHILICITY RELATIONS in .NET framework Encoder Data Matrix 2d barcode in .NET framework PERMEABILITY LIPOPHILICITY RELATIONS PERMEABILITY LIPOPHILICITY RELATIONSDataMatrix Recognizer In .NET FrameworkUsing Barcode Control SDK for .NET framework Control to generate, create, read, scan barcode image in .NET framework applications.v1 C1 0 v1 C1 1 v2 C2 1 v3 C3 1 Two partition coef cients need to be de ned: K p2 C2 1 =C1 1 and K p3 C3 1 =C1 1 With these, the mass balance may be rewritten as v1 C1 0 v1 C1 1 v2 Kp2 C1 1 v3 Kp3 C1 1 C1 1 v1 v2 Kp2 v3 Kp3 If the organic : aqueous volume ratios are r2 and r3, then the equilibrium concentrations in the three phases can be stated as C1 1 C2 1 C3 1 C1 0 1 r2 Kp2 r3 Kp3 C1 0 Kp2 1 r2 Kp2 r3 Kp3 C1 0 Kp3 1 r2 Kp2 r3 Kp3 7:38 7:39 7:40 Printing Data Matrix In VS .NETUsing Barcode printer for .NET framework Control to generate, create ECC200 image in Visual Studio .NET applications.Further reduction is possible To a good approximation, partition coef cients from different organic solvents may be interrelated by the so-called Collander equation a [364,587]: log Kp3 a log Kp2 c, or Kp3 10c Kp2, where a and c are constants Equations (738) (740) can be expressed in log forms as a function of just one partition coef cient (ie, Kp Kp2): Water : Lipid : Receptor : log log log C1 1 a log 1 r2 Kp r3 10c Kp C1 0 C2 1 a log Kp log 1 r2 Kp r3 10c Kp C1 0 C3 1 a a log Kp log 1 r2 Kp r3 10c Kp c C1 0 7:41 7:42 7:43 Scanning ECC200 In VS .NETUsing Barcode decoder for .NET framework Control to read, scan read, scan image in .NET framework applications.Figure 720 is a sample plot of relative equilibrium concentrations, Eqs (741) (743) In the example, the three phases were picked to be water, octanol, and phosphatidylcholine-based liposomes (vesicles consisting of a phospholipid bilayer), with the volumes v1 1 mL (water), v2 50 mL (octanol), and v3 10 mL (liposomes) The Collander equation was deduced from Fig 56: log Kp,liposome 041 log Kp,oct 204 Figure 720 suggests that when very hydrophilic molecules (with log Kp,oct < 6) are placed into this three-phase mixture, most of them distribute into the water phase (solid curve), with only minor liposome phase occupation (dashed-dotted curve), but virtually no octanol phase occupation (dashed curve) In the example, molecules with log Kp,oct of 4 to 3, mostly reside in the liposome fraction, schematically modeling the lipophilic property of a hypothetical receptor site, reaching maximum occupancy for compounds with log Kp,oct at about 15 Very lipophilic molecules, with log Kp,oct > 5 preferentially concentrate in the (more lipophilic) octanol compartment, becoming unavailable to the receptor regionPainting Barcode In .NETUsing Barcode creation for Visual Studio .NET Control to generate, create bar code image in VS .NET applications.PERMEABILITY Bar Code Scanner In .NET FrameworkUsing Barcode scanner for .NET framework Control to read, scan read, scan image in .NET framework applications.10 L liposome Make Data Matrix 2d Barcode In C#Using Barcode creator for Visual Studio .NET Control to generate, create ECC200 image in .NET applications.50 L octanol Painting Data Matrix ECC200 In .NETUsing Barcode generation for ASP.NET Control to generate, create ECC200 image in ASP.NET applications.log C / Co ECC200 Printer In Visual Basic .NETUsing Barcode maker for Visual Studio .NET Control to generate, create Data Matrix image in VS .NET applications.0 -2 -4Universal Product Code Version A Printer In .NET FrameworkUsing Barcode generation for VS .NET Control to generate, create UCC - 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